New hopes for gene therapy

New hopes for gene therapy

Hopes were running high at the end of the 20th century. The newly hatched internet economy took off, the Cold War was consigned to history, two separate teams were racing to sequence the human genome, and once that was in the databanks, surely we would understand much more about our diseases and develop new cures based on the genetic insights. And Al Gore might become US president and do someth...

Gene Therapy for Pancreatic Cancer: Specificity, Issues and Hopes

A recent death projection has placed pancreatic ductal adenocarcinoma as the second cause of death by cancer in 2030. The prognosis for pancreatic cancer is very poor and there is a great need for new treatments that can change this poor outcome. Developments of therapeutic innovations in combination with conventional chemotherapy are needed urgently. Among innovative treatments the gene therap...

Interventional therapy for resistant hypertension: new hopes and old concerns!

Hypertension contributes to 62% of all strokes and 49% of all cases of heart disease and is the most prevalent controllable disease in developed countries, affecting 20–50% of adult population [1]. Nevertheless, it has been estimated that only 5–30% of patients with hypertension achieve adequate blood pressure control [2], with challenges to obtain target values mainly ascribed to insufficient ...

Novel combined candidate--new hopes for COPD maintenance therapy!?

New hopes for neurologically disabled.

The later half of the twentieth century witnessed rapid advances in our understanding of the nervous system, in health and disease, as a result of developments in diverse fields. Beginning in the 1950’s, neurochemical and neuropharmacological investigations resulted in the identification of a host of neurotransmitters, neuromodulators, neurohormones, the mechanisms of their storage, release, re...